diff --git a/changelog/unreleased/issue-2427 b/changelog/unreleased/issue-2427
new file mode 100644
index 000000000..ecd6f88fc
--- /dev/null
+++ b/changelog/unreleased/issue-2427
@@ -0,0 +1,7 @@
+Enhancement: Add flag `--iexclude-file` to backup command
+
+The backup command now supports the flag `--iexclude-file` which is a
+case-insensitive version of `--exclude-file`.
+
+https://github.com/restic/restic/issues/2427
+https://github.com/restic/restic/pull/2898
diff --git a/cmd/restic/cmd_backup.go b/cmd/restic/cmd_backup.go
index f410fb1fd..7aa9a1d09 100644
--- a/cmd/restic/cmd_backup.go
+++ b/cmd/restic/cmd_backup.go
@@ -78,22 +78,23 @@ Exit status is 3 if some source data could not be read (incomplete snapshot crea
 
 // BackupOptions bundles all options for the backup command.
 type BackupOptions struct {
-	Parent              string
-	Force               bool
-	Excludes            []string
-	InsensitiveExcludes []string
-	ExcludeFiles        []string
-	ExcludeOtherFS      bool
-	ExcludeIfPresent    []string
-	ExcludeCaches       bool
-	Stdin               bool
-	StdinFilename       string
-	Tags                []string
-	Host                string
-	FilesFrom           []string
-	TimeStamp           string
-	WithAtime           bool
-	IgnoreInode         bool
+	Parent                  string
+	Force                   bool
+	Excludes                []string
+	InsensitiveExcludes     []string
+	ExcludeFiles            []string
+	InsensitiveExcludeFiles []string
+	ExcludeOtherFS          bool
+	ExcludeIfPresent        []string
+	ExcludeCaches           bool
+	Stdin                   bool
+	StdinFilename           string
+	Tags                    []string
+	Host                    string
+	FilesFrom               []string
+	TimeStamp               string
+	WithAtime               bool
+	IgnoreInode             bool
 }
 
 var backupOptions BackupOptions
@@ -110,6 +111,7 @@ func init() {
 	f.StringArrayVarP(&backupOptions.Excludes, "exclude", "e", nil, "exclude a `pattern` (can be specified multiple times)")
 	f.StringArrayVar(&backupOptions.InsensitiveExcludes, "iexclude", nil, "same as --exclude `pattern` but ignores the casing of filenames")
 	f.StringArrayVar(&backupOptions.ExcludeFiles, "exclude-file", nil, "read exclude patterns from a `file` (can be specified multiple times)")
+	f.StringArrayVar(&backupOptions.InsensitiveExcludeFiles, "iexclude-file", nil, "same as --exclude-file but ignores casing of `file`names in patterns")
 	f.BoolVarP(&backupOptions.ExcludeOtherFS, "one-file-system", "x", false, "exclude other file systems")
 	f.StringArrayVar(&backupOptions.ExcludeIfPresent, "exclude-if-present", nil, "takes `filename[:header]`, exclude contents of directories containing filename (except filename itself) if header of that file is as provided (can be specified multiple times)")
 	f.BoolVar(&backupOptions.ExcludeCaches, "exclude-caches", false, `excludes cache directories that are marked with a CACHEDIR.TAG file. See https://bford.info/cachedir/ for the Cache Directory Tagging Standard`)
@@ -239,6 +241,14 @@ func collectRejectByNameFuncs(opts BackupOptions, repo *repository.Repository, t
 		opts.Excludes = append(opts.Excludes, excludes...)
 	}
 
+	if len(opts.InsensitiveExcludeFiles) > 0 {
+		excludes, err := readExcludePatternsFromFiles(opts.InsensitiveExcludeFiles)
+		if err != nil {
+			return nil, err
+		}
+		opts.InsensitiveExcludes = append(opts.InsensitiveExcludes, excludes...)
+	}
+
 	if len(opts.InsensitiveExcludes) > 0 {
 		fs = append(fs, rejectByInsensitivePattern(opts.InsensitiveExcludes))
 	}
diff --git a/doc/040_backup.rst b/doc/040_backup.rst
index 4185bb914..a3a354475 100644
--- a/doc/040_backup.rst
+++ b/doc/040_backup.rst
@@ -142,6 +142,7 @@ the exclude options are:
 -  ``--iexclude`` Same as ``--exclude`` but ignores the case of paths
 -  ``--exclude-caches`` Specified once to exclude folders containing a special file
 -  ``--exclude-file`` Specified one or more times to exclude items listed in a given file
+-  ``--iexclude-file`` Same as ``exclude-file`` but ignores cases like in ``--iexclude``
 -  ``--exclude-if-present foo`` Specified one or more times to exclude a folder's content if it contains a file called ``foo`` (optionally having a given header, no wildcards for the file name supported)
 
 Please see ``restic help backup`` for more specific information about each exclude option.
diff --git a/doc/manual_rest.rst b/doc/manual_rest.rst
index e2fc51a6e..76ced2653 100644
--- a/doc/manual_rest.rst
+++ b/doc/manual_rest.rst
@@ -97,6 +97,7 @@ command:
       -h, --help                                   help for backup
       -H, --host hostname                          set the hostname for the snapshot manually. To prevent an expensive rescan use the "parent" flag
           --iexclude pattern                       same as --exclude pattern but ignores the casing of filenames
+          --iexclude-file file                     same as --exclude-file but ignores casing of filenames in patterns
           --ignore-inode                           ignore inode number changes when checking for modified files
       -x, --one-file-system                        exclude other file systems
           --parent snapshot                        use this parent snapshot (default: last snapshot in the repo that has the same target files/directories)